Command: ht_neuron

Description

This model neuron implements a slightly modified version of the

neuron model described in [1]. The most important properties are:

- Integrate-and-fire with threshold that is increased on spiking

and decays back to an equilibrium value.

- No hard reset but repolarizing potassium current.

- AMPA NMDA GABA_A and GABA_B conductance-based synapses with

beta-function (difference of two exponentials) time course.

- Intrinsic currents I_h (pacemaker) I_T (low-threshold calcium)

I_Na(p) (persistent sodium) and I_KNa (depolarization-activated

potassium).

In comparison to the model described in the paper the following

modifications were mare:

- NMDA conductance is given by g(t) = g_peak * m(V) where

m(V) = 1 / ( 1 + exp( - ( V - NMDA_Vact ) / NMDA_Sact ) )

This is an approximation to the NMDA model used in [2].

- Several apparent typographical errors in the descriptions of

the intrinsic currents were fixed hopefully in a meaningful

way.

I'd like to thank Sean Hill for giving me access to his

simulator source code.

See examples/hilltononi for usage examples.

Warning:

THIS MODEL NEURON HAS NOT BEEN TESTED EXTENSIVELY!

Parameters

V_m - membrane potential

spike_duration - duration of re-polarizing potassium current

Tau_m - membrane time constant applying to all currents but repolarizing K-current

(see [1 p 1677])

Tau_spike - membrane time constant applying to repolarizing K-current

Theta Theta_eq Tau_theta - Threshold equilibrium value time constant

g_KL E_K g_NaL E_Na - conductances and reversal potentials for K and Na leak currents

{AMPA NMDA GABA_A GABA_B}_{E_rev g_peak Tau_1 Tau_2}

- reversal potentials peak conductances and time constants for synapses

(Tau_1: rise time Tau_2: decay time Tau_1 < Tau_2)

NMDA_Sact NMDA_Vact - Parameters for voltage dependence of NMDA-synapse see eq. above

{h T NaP KNa}_{E_rev g_peak} - reversal potential and peak conductance for intrinsic currents

receptor_types - dictionary mapping synapse names to ports on neuron model

recordables - list of recordable quantities.

Author

Hans Ekkehard Plesser

Sends

SpikeEvent

Receives

SpikeEvent
CurrentEvent
DataLoggingRequest

[1] S Hill and G Tononi (2005). J Neurophysiol 93:1671-1698.

[2] ED Lumer GM Edelman and G Tononi (1997). Cereb Cortex 7:207-227.

References

[1] S Hill and G Tononi (2005). J Neurophysiol 93:1671-1698.

[2] ED Lumer GM Edelman and G Tononi (1997). Cereb Cortex 7:207-227.

File

models/ht_neuron.h

FirstVersion