Dear Aadhar, Enable and Disable functions for structural plasticity apply to the whole network. What I do to disable subnetworks is to set their growth rate to 0 and back to the original value when you want to activate them. This is possible because you can assign different growth rules to each subnetwork and/or to each synapse type which can grow between specific synaptic elements. Below you can see an example for NEST 2.20. All the best, Sandra **********        # At network definition         growth_curve = {'growth_curve': "gaussian",             'growth_rate': 0.0000, # (elements/ms)             'continuous': False,             'eta': -0.005,# Ca2+             'eps': 0.075, # Ca2+         }         synaptic_elements_e = {'Den_ex': growth_curve, 'Axon_ex': growth_curve}         neurons = nest.Create('iaf_psc_alpha', 2,{'synaptic_elements': synaptic_elements_e})         ps = nest.Create('poisson_generator_ps', params={'rate': 1000.})         nest.Connect(ps, neurons)         nest.Connect(neurons, neurons)         nest.SetKernelStatus({'structural_plasticity_synapses':            {'exsynapse':            {'model': 'static_synapse',             'post_synaptic_element': 'Den_ex',             'pre_synaptic_element': 'Axon_ex',            }}})         # Make SP ON         growth_curve_on = {             'growth_rate': 0.005,             'eta': -0.005,             'eps': 0.03,         }         synaptic_elements_on = {'Den_ex': growth_curve_on, 'Axon_ex': growth_curve_on}         nest.SetStatus(neurons, 'synaptic_elements_param', synaptic_elements_on)         nest.Simulate(300)         print("SP ON: {}\n".format(nest.GetStatus(neurons, 'synaptic_elements')))         # Make SP OFF         growth_curve_off = { 'growth_rate': 0.0, }         synaptic_elements_off = {'Den_ex': growth_curve_off, 'Axon_ex': growth_curve_off}         nest.SetStatus(neurons, 'synaptic_elements_param', synaptic_elements_off)         nest.Simulate(300)         print("SP OFF: {}\n".format(nest.GetStatus(neurons, 'synaptic_elements'))) ********** On 09.11.21 20:43, Aadhar Sharma wrote: